ИСПОЛЬЗОВАНИЕ АМЕЛОГЕНИНА ПРИ ЛЕЧЕНИИ КАРИЕСА

Зубная эмаль является самой твердой тканью в организме человека. Зрелая эмаль является неживой тканью и не может регенерировать после существенной потери минералов, которая часто возникает из-за кариеса или эрозии. Несмотря на усилия по реминерализации эмали, профилактика и лечение начальных кариозных поражений и субмикрометрической эрозии по-прежнему являются основными клиническими проблемами. В настоящее время подобные поражения обрабатывают удалением измененной ткани и заполнением полученной полости реставрационными материалами. В качестве потенциальной альтернативы традиционному лечению биомиметическая реконструкция зубной эмали может регенеририровать организованные эмалево-имитирующие кристаллы апатита с надежной привязкой к поверхности натуральной эмали.

гидрогель амелогенин-хитозан, биомиметик эмали, рН-циклирование, эрозия эмали, раннее кариозное поражение

1. Altarabulsi M. B. Clinical safety, quality and effect of resin infiltration for proximal caries / M. B. Altarabulsi, M. Alkilzy, M. A. Petrou //Eur. J. paediatr. dent. - 2014. - V. 15 (1). - P. 39-44.

2. Arends J. The nature of early caries lesions in enamel /J. Arends, J. Christoffersen //J. Dent. Res. - 1986. - № 65. - P. 2-11.

3. Arnaud T. M. Chitosan effect on dental enamel deremineralization: An in vitro evaluation /T. M. Arnaud, B. D. Neto, F. B. Diniz //J. Dent. - 2010. - № 8. - P. 848-852.

4. Bonde J. S. Use of human amelogenin in molecular encapsulation for the design of pH responsive microparticles /J. S. Bonde, L. Bulow // BMC Biotechnol. - 2012. - №12. - P. 34-39.

5. Buzalaf M. A. PH-cycling models for in vitro evaluation of the efficacy of fluoridated dentifrices for caries control: strengths and limitations /M. A. Buzalaf, A. R. Hannas, A. C. Magalhaes //J. Appl. Oral. Sci. - 2010. - №18. -P. 316-334.

6. Cummins. Working Group Report 3: Role of models in assessing new agents for caries prevention /Adv. Dent. Res. - 1995. - №9. - P. 338339.

7. De Almeida Pdel V. Saliva composition and functions: a comprehensive review /V. de Almeida Pdel, A. M. Gregio, M. A. Machado //J. Contemp. Dent. Pract. - 2008. - №9. - P. 72-80.

8. De Marsillac Mde W. Assesment of artificial caries lesions through scanning electron microscopy and cross-sectional microhardness test / W. de Marsillac Mde, S. Vieira Rde //Indian J. Dent. Res. - 2013. - №24. - P. 249-254.

9. Eccles J. D. Dental erosion of nonindustrial origin. A clinical survey and classification //J. Prosthet Dent. - 1979. - №42. - P. 649-653.

10. Featherstone J. D. The role of remineralizing and anticaries agents in caries management /J. D. Featherstone, S. Domejean //Adv. dent. res. - 2012. - V. 24 (2). - P. 28-31.

11. Ferreira J. M. Therapeutic effect of two fluoride varnishes 13. //Braz. oral. on proximal caries infiltration: three-year follow-up. - 2009. -V. 23 (4). - P. 446-451.

12. Hannig M. Nanomaterials in preventive dentistry /M. Hannig, C. Hannig //Nat. Nanotechnol. - 2010. - №5. - P. 565-569.

13. Humphrey S. P. A review of saliva: Normal composition, flow, and function /S. P. Humphrey, R. T. Williamson //J. Prosthet. Dent. -2001. - №85. - P. 162-169.

14. Jain P. Dental caries and social deprivation /P. Jain, A.Shankar, S. Ramaiah //Lancet. -2007. - №369. - Р. 639.

15. Kumar M. N. A review of chitin and chitosan applications //React. Funct. Polym. - 2000. - №46. - P. 1-27.

16. Lee H. S. Chitosan adsorption on hydroxyapatite and its role in preventing acid erosion /H. S. Lee, S. Tsai, C. C. Kuo //J. Colloid. Interf. Sci. - 2012. - №385. - P. 235-243.

17. Li J. L. Long-term remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo: A systematic review /J. L. Li, X. Xiaoqiu, Yu. Wang //J. Dent. - 2014. - №42. - P. 769-777.

18. Liu W. G. An investigation on the physicochemical properties of chitosan /W. G. Liu, S. J. Sun, Z. Q. Cao et al. //DNA polyelectrolyte complexes. Biomaterials. - 2005. - №26. - P. 27052711.

19. Lussi A. The influence of different factors on in vitro enamel erosion /A. Lussi, T. Jaggi, S. Scharer //Caries. Res. - 1993. - №27. - P. 387 -393.

20. Meurman J. H. Salivary Ph and Glucose after Consuming Various Beverages, Including Sugar-Containing Drinks /J. H. Meurman, I. Rytomaa, K. Kari et al. //Caries Research. - 1987. -№21. - P. 353-359.

21. Meyer-Lueckel H. Improved resin infiltration of natural /H. Meyer-Lueckel, S. Paris //J. dent. res. - 2008. - V. 87 (12). - Р. 1112-1116.

22. Moradian-Oldak J. Protein-mediated enamel mineralization //Front Biosci-Landmark. - 2012. - №17. - P. 1996-2023.

23. Paris S. Infiltration of natural caries lesions with experimental resins differing in penetration coefficients and ethanol addition /S. Paris, H. Meyer-Luckel //Journ. of dental research. -2010. - V. 44 (4). - P. 408-414.

24. Paris S. Resin infiltration of natural caries lesions /S. Paris, H. Meyer-Luckel, A. Kielbassa //Journ. of dental research. - 2007. - V. 86 (7). - P. 662-666.

25. Paris S. Improved resin infiltration of natural caries lesions /S. Paris, H. Meyer-Luckel // Journ. of dental research. - 2008. - V. 87 (12). -P. 1112-1116.

26. Paris S. Penetration coefficients of commercially available and experimental composites intended to infiltrate enamel carious lesions /S. Paris, H. Meyer-Luckel, A. Kielbassa //Dent. mater. - 2007. - V. 23 (6). - P. 742-748.

27. Paris S. Surface layer erosion of natural caries lesions with phosphoric and hydrochloric acid gels in preparation for resin infiltration /S. Paris, H. Meyer-Luckel, A. Kielbassa //Journ. of dental research. - 2007. - V. 41 (3). - P. 223230.

28. Paris S. Micro-hardness and mineral loss of enamel lesions after infiltration with various resins: influence of infiltrant composition and application frequency in vitro /S. Paris, H. Meyer-Luckel, S. Seddig //Journ. of dental research. - 2013. - V. 41 (6). - P. 543-548.

29. Pinto C. F. Effect of 10% carbamide peroxide bleaching on sound and artificial enamel carious lesions /C. F. Pinto, A. F. Paes Leme, V. Cavalli //Braz. Dent. J. - 2009. - №20. - P. 4853.

30. Ruan Q. C. Amelogenin and enamel biomimetics /Q. C. Ruan, J. Moradian-Oldak // Journ. of Materials Chemistry B. - 2015. - №3. -P. 3112-3129.

31. Ruan Q. C. An amelogenin-chitosan matrix promotes assembly of an enamel-like layer with a dense interface /Q. C. Ruan, Yu. Zhang, X. Yang et al. //Acta Biomater. - 2013. - №9. - P. 7289-7297.

32. Ruan Q. C. Development of Amelogenin-chitosan Hydrogel for In vitro Enamel Regrowth with a Dense Interface /Q. C. Ruan, J. Moradian-Oldak //J. Vis. Exp. - 2014. - V. 16. - P. 89.

33. Ruan Q. C. Amelogenin-chitosan matrix for human enamel regrowth: effects of viscosity and supersaturation degree /Q. C. Ruan, N. Siddiqah, X. C. Li //Connective Tissue Research. - 2014. - №55. - P. 150-154.

34. Selwitz R. H. Dental caries /R. H. Selwitz, A. I. Ismail, N. B. Pitts //Lancet. - 2007. -№369. - P. 51-59.

35. Ten Cate J. M. Alternating demineralization and remineralization of artificial enamel lesions /J. M. ten Cate, P. P. Duijsters //Caries Research. - 1982. - №16. - P. 201-210.

36. Ten Cate J. M. Models and role models //Caries Research. - 2015. - №49. - P. 3-10.

37. Tomihata K. In vitro and in vivo degradation of films of chitin and its deacetylated derivatives /K. Tomihata, Y. Ikada //Biomaterials. -1997. - №18. - P. 567-575.

38. Vashisht R. Remineralization of early enamel lesions using casein phosphopeptide amorphous calcium Phosphate: an ex-vivo study / R. Vashisht, A. Kumar, R. Indira //Contemp. Clin. Dent. - 2010. - №1. - P. 210-213.

39. White D. J. The application of in vitro models to research on demineralization and remineralization of the teeth //Journ. of Applied Oral Science. - 1995. - №9. - P. 175-193.

40. Yang Y. 8DSS-promoted remineralization of initial enamel caries in vitro /Y. Yang, X. P. Liv, W. Shi //J. Dent. Res. - 2014. - № 93. - P. 520-524.

41. Yengopal V. Caries preventive effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP): a meta-analysis /V. Yengopal, S. Mickenautsch //Acta. Odontol. Scand. - 2009. - №67. - P. 321-332.

42. Zero D. T. In situ caries models //Journ. of Applied Oral Science. - 1995. - № 9. - P. 214230.