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Медицина и экология

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ВИРУЛЕНТНЫЙ ACINETOBACTER BAUMANNII

Аннотация

В последние годы Acinetobacter baumannii является одним из важнейших нозокомиальных патогенов, распространенных по всему миру. A. baumannii известен своей способностью выживать в течение длительного периода времени в госпиталях, склонен к развитию множественной устойчивости к антибиотикам, также несомненна его роль в развитии серьезных инфекций у критических пациентов. В статье описаны основные факторы вирулентности A. baumannii - пили, липополисахариды, везикулы наружной мембраны, липазы, биопленки, эндотоксин, капсульный полисахарид, система секреции. Описанные факторы вирулентности и накопленные механизмы устойчивости формируют серьезный внутрибольничный патоген.

Об авторе

А. В. Лавриненко
НАО «Медицинский университет Караганды»
Казахстан


Список литературы

1. Алексеева Е. И. Некоторые особенности эпидемического процесса внутрибольничных инфекций в детских ожоговых отделениях /Е. И. Алексеева, А. В. Слободенюк //Гигиена и эпидемиология. - 2007. - V. 1 (39). - P. 93 -95.

2. Acinetobacter baumannii is dependent on the type II secretion system and its substrate LipA for lipid utilization and in vivo fitness /T. L. Johnson, U. Waack, S. Smith et al. //J. Bacteriol. - 2015. - V. 198. - P. 711-719.

3. Acinetobacter baumannii outer membrane protein A targets the nucleus and induces cytotoxicity /C. H. Choi, S. H. Hyun, J. Y. Lee et al. //Cell Microbiol. - 2008. - V. 10. - P. 309-319.

4. Acinetobacter baumannii utilizes a type VI secretion system for bacterial competition /M.D. Carruthers, P. A. Nicholson, E. N. Tracy et al. //PLoS ONE. - 2013. - V. 8. - e59388.

5. Acinetobacter: an emerging pathogen with a versatile secretome /M. Noha, L. Elhosseiny, A. Ahmed et al. //Elhosseiny and Attia Emerging Microbes & Infections. - 2018. - V. 7. -P. 33.

6. Alcoforado D. J. Molecular weaponry: diverse effectors delivered by the Type VI secretion system /D. J. Alcoforado, Y. C. Liu //Cell. Microbiol. - 2015. - V. 17. - P. 1742-1751.

7. Assessment of biofilm formation and resistance to imipenem and ciprofloxacin among clinical isolates of Acinetobacter baumannii in Tehran /A. Abdi-Ali, S. Hendiani, P. Mohammadi et al. //Microbiol. - 2014. - V. 7 (1). - P. 166168.

8. Assessment of insertion sequence mobilization as an adaptive response to oxidative stress in Acinetobacter baumannii using IS-Seq. / M. S. Wright, S. Mountain, K. Beeri et al. //J. Bacteriol. - 2017. - V. 199. - e00833-16.

9. Attachment to and biofilm formation on abiotic surfaces by Acinetobacter baumannii: involvement of a novel chaperone-usher pili assembly system /A. P. Tomaras, C. W. Dorsey, R. E. Edelmann et al. //Microbiol. - 2003. - V. 149. -P. 3473-3484.

10. Badave G. K. Biofilm Producing Multidrug Resistant Acinetobacter baumannii: An Emerging Challenge /G. K. Badave, D. Kulkarni // J. Clin. Diagn. Res. - 2015. - V. 9. - P. 8-9.

11. Bentancor L. V. Identification of Ata, a multifunctional trimeric autotransporter of Acinetobacter baumannii /L. V. Bentancor, A. Camacho-Peiro, C. Bozkurt-Guzel et al. //J. Bacteriol. - 2012. - V. 194. - P. 3950-3960.

12. Bergogne-Berezin E. Acinetobacter: Biology and Pathogenesis /E. Bergogne-Berezin, H. Friedman, M. Bendinelli //New York: Springer. - 2008. - P. 236.

13. Biofilm formation in Acinetobacter baumannii: associated features and clinical implications /J. Rodriguez-Bano, S. Marti, S. Soto et al. //Clin. Microbiol. Infect. - 2008. - V. 14. - P. 276-278.

14. Biofilm formation in clinical isolates of nosocomial Acinetobacter baumannii and its relationship with multidrug resistance /E. Babapour, A. Haddadi, R. Mirnejad et al. //Asian Pac. J. Trop. Biomed. - 2016. - V. 6 (6). - P. 528-533.

15. Brade H. Biological activities of the lipopolysaccharide and lipid A from Acinetobacter calcoaceticus /H. Brade, C. Galanos //J. Med. Microbiol. - 1983. - V. 16 (2). - P. 211-214.

16. Bravo Z. The long-term survival of Acinetobacter baumannii ATCC 19606T under nutrient-deprived conditions does not require the entry into the viable but non-culturable state // Arch. Microbiol. - 2016. - V. 198. - P. 399-407.

17. Brossard K. A. The Acinetobacter baumannii biofilmassociated protein plays a role in adherence to human epithelial cells /K. A. Brossard, A. A. Campagnari //Infect Immun. -2012. - V. 80 (1). - P. 228-233.

18. Cerqueira G. M. Insights into Acinetobacter baumannii pathogenicity /G. M. Cerqueira, A. Y. Peleg //IUBMB Life. - 2011. - V. 63 (12). -P. 1055-1060.

19. Characterization of bacterial biofilms formed on urinary catheters /R. Djeribi, W. Bouchloukh, T. Jouenne et al. //Am. J. Infect. Control. - 2012. - V. 40. - P. 854-859.

20. Clinical isolates of Acinetobacter baumannii from a Portuguese hospital: PFGE characterization, antibiotic susceptibility and biofilmforming ability /A. Duarte, S. Ferreira, S. Almeida et al. //Comp. Immunol. Microbiol. Infect. Dis. -2016. - V. 45. - P. 29-33.

21. Costs of healthcare and community-associated infections with antimicrobial-resistant versus antimicrobialsusceptible organisms /M. J. Neidell, B. Cohen, Y. Furuya et al. //Clin. Infect. Dis. - 2012. - V. 55. - P. 807-822.

22. De Gregorio E. Biofilm-associated proteins: news from Acinetobacter //BMC Genomics. - 2015. - V. 16. - P. 933.

23. Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity /L. C. Antunes, F. Imperi, A. Carattoli et al. //PLoS ONE. - 2011. - V. 6. - e22674.

24. Donlan R. M. Biofilms: survival mechanisms of clinically relevant microorganisms /R. M. Donlan, J. W. Costerton //Clin. Microbiol. Rev. -2002. - V. 15. - P. 67-193.

25. Effect of incubation temperature on antibiotic resistance and virulence factors of Acinetobacter baumannii ATCC 17978 /P. M. De Silva, P. Chong, D. M. Fernando et al. //Antimicrob. Agents. Chemother. - 2018. - V. 62 (1). -e01514-01517.

26. Effect of temperature and plumbing materials on biofilm formation by Legionella pneumophila serogroup 1 and 2-15 /A. Assaidi, M. Ellouali, H. Latrache et al. //J. Adhes. Sci. Technol. - 2018. - P. 1-14.

27. Eijkelkamp B. A. H-NS plays a role in expression of Acinetobacter baumannii virulence features //Infect. Immun. - 2013. - V. 81. - P. 2574-2583.

28. Epidemiology and impact of imipenem resistance in Acinetobacter baumannii /E. Lautenbach, M. Synnestvedt, M. G. Weiner et al. // Infect. Control Hosp. Epidemiol. - 2009. - V. 30. - P. 1186-1278.

29. Falagas M. E. Attributable mortality of Acinetobacter baumannii: no longer a controversial issue /M. E. Falagas, P. I. Rafailidis //Crit. Care. - 2007. - V. 11. - P. 134.

30. Gayoso C. M. Molecular mechanisms involved in the response to desiccation stress and persistence in Acinetobacter baumannii // Proteome Res. - 2014. - V. 13. - P. 460-476.

31. Giannouli M. Virulence-related traits of epidemic Acinetobacter baumannii strains belonging to the international clonal lineages I-III and to the emerging genotypes ST25 and ST78 //BMC Infect. Dis. - 2013. - V. 13. - P. 282.

32. Goh H. M. Molecular analysis of the Acinetobacter baumannii biofilm-associated protein //Appl. Environ. Microbiol. - 2013. - V. 79. -P. 6535-6543.

33. Harding C. M. Pathogenic Acinetobacter species have a functional type I secretion system and contactdependent inhibition systems //J. Biol. Chem. - 2017. - V. 292. - P. 9075-9087.

34. Harding C. M. Uncovering the mechanisms of Acinetobacter baumannii virulence /C. M. Harding, S. W. Hennon, M. F. Feldman //Nat. Rev. Microbiol. - 2018. - V. 16 (2). - P. 91-102.

35. Identification and characterization of a glycosyltransferase involved in Acinetobacter baumannii lipopolysaccharide core biosynthesis /N. R. Luke, S. L. Sauberan, T. A. Russo et al. //Infect Immun. - 2010. - V. 78. - P. 2017-2023.

36. Influence of temperature and surface kind on biofilm formation by Staphylococcus aureus from food-contact surfaces and sensitivity to sanitizers /Q. G. da Silva Meira, I. de Medeiros Barbosa, A. A. Athaydeet al. //Food Control. -2012. - V. 25 (2). - P. 469-475.

37. Influence of the alginate production on cell-to-cell communication in Pseudomonas aeruginosa PAO1 /J. Yang, M. Toyofuku, R. Sakai et al. //Environ. Microbiol. Rep. - 2017. - V. 9 (3). - P. 239-249.

38. Jun S. H. Acinetobacter baumannii outer membrane vesicles elicit a potent innate immune response via membrane proteins //PLoS ONE. - 2013. - V. 8. - e71751.

39. Juttukonda L. J. Acinetobacter baumannii coordinates urea metabolism with metal import to resist host-mediated metal limitation /L.J. Juttukonda W. J. Chazin, E. P. Skaar //mBio. -2016. - e01475-16.

40. Kinsella R. L. Defining the interaction of the protease CpaA with its type II secretion-chaperone CpaB and its contribution to virulence in Acinetobacter species //J. Biol. Chem. - 2017. - 808394.

41. Loehfelm T. W. Identification and characterization of an Acinetobacter baumannii biofilm-associated protein /T. W. Loehfelm, N. R. Luke, A. A. Campagnari //J. Bacteriol. - 2008. -V. 190 (3). - P. 1036-1044.

42. Longo F. Biofilm formation in Acinetobacter baumannii /F. Longo, C. Vuotto, G. Donelli //New Microbiologica. - 2014. - V. 37. -P. 119-127.

43. McConnell M. J. Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models /M. J. McConnell, L. Actis, J. Pachon //FEMS Microbiol. Rev. - 2013. - V. 37. P. 130-155.

44. Medically relevant acinetobacter species require a type II secretion system and specific membrane-associated chaperones for the export of multiple substrates and full virulence /C. M. Harding, R. L. Kinsella, L. D. Palmer et al. // PLoS Pathog. - 2016. - V. 12. - e1005391.

45. Molecular analysis and expression of bap gene in biofilm-forming multi drug-resistant Acinetobacter baumannii /O. Azizi, F. Shahcheraghi, H. Salimizand et al. //Rep. Biochem. Mol. Bio. - 2016. - V. 5 (1). - P. 62.

46. Multidrug resistance related to biofilm formation in Acinetobacter baumannii and Klebsiella pneumonia clinical strains from different pulsotype /P. A. de Campos, S. Royer, D. W. da Fonseca Batistao et al. //Curr. Microbiol. - 2016. - V. 72 (5). - P. 617-627.

47. Multi-resistant infections in repatriated patients after natural disasters: lessons learned from the 2004 tsunami for hospital infection control /I. Ugkay, H. Sax, S. Harbarth et al. //J. Hosp. Infect. - 2008. - V. 68. - P. 1-8.

48. Norton M. D. Antibiotic resistance acquired through a DNA damage-inducible response in Acinetobacter baumannii /M. D. Norton, A. J. Spilkia, V. G. Godoy //J. Bacteriol. - 2013. - V. 195. - P. 1335-1345.

49. Nowak P. Acinetobacter baumannii: biology and drug resistance - role of car-bapenemases /P. Nowak, P. Paluchowska //Folia histochemica et cytobiologica. - 2016. - V. 54 (2). - P. 61-74.

50. Peleg A. Y. Acinetobacter baumannii: emergence of a successful pathogen /A. Y. Peleg, H. Seifert, D. L. Paterson //Clin. Microbiol. Rev. -2008. - V. 21. - P. 538-620.

51. Penicillin-binding protein 7/8 contributes to the survival of Acinetobacter baumannii in vitro and in vivo /T. A. Russo, U. MacDonald, J. M. Beanan et al. //j. Infect. Dis. - 2009. - V. 199. - P. 513-521.

52. Perez A. The FhaB/FhaC two-partner secretion system is involved in adhesion of Acinetobacter baumannii AbH12O-A2 strain // Virulence. - 2016. - V. 8. - P. 959-974.

53. Potts M. Desiccation tolerance of prokaryotes //Microbiol. Rev. - 1994. - V. 58. - P. 755-805.

54. Prevalence and mapping of a plasmid encoding a type IV secretion system in Acinetobacter baumannii /C. C. Liu, H. Y. Kuo, C. Y. Tang et al. //Genomics. - 2014. - V. 104. - P. 215-223.

55. Proteome analysis of outer membrane vesicles from a clinical Acinetobacter baumannii isolate /S. O. Kwon, Y. S. Gho, J. C. Lee et al. // FEMS Microbiol. Lett. - 2009. - V. 297. - P. 150156.

56. Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence /S. Moreno-Gamez, R. A. Sorg, A. Domenech et al. //Nat. Commun. -2017. - V. 8 (1). - P. 854.

57. Ramos-Gallardo G. Chronic wounds in burn injury: a case report on importance of biofilms //World. J. Plast. Surg. - 2016. - V. 5(2). -P. 175.

58. Risk of hand or glove contamination after contact with patients colonized with vancomycin-resistant Enterococcus or the colonized patients' environment /M. K. Hayden, D. W. Blom, E. A. Lyle et al. //Infect. Control Hosp. Epidemiol. - 2008. - V. 29. - P. 149-154.

59. Sievert D. M. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010 // Infect. Control Hosp. Epidemiol. - 2013. - V. 34. - P. 1-14.

60. Stewart P. S. Antibiotic resistance of bacteria in biofilms /P. S Stewart, J. W. Costerton //The Lancet. - 2001. - V. 358 (9276). -P.135-138.

61. The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned PanDrug-Resistant Menace /I. Roca, P. Espinal, X. Vila-Farres et al. //Front Microbiol. - 2012. - V. 3. - P. 148.

62. The K1 capsular polysaccharide of Acinetobacter baumannii strain 307-0294 is a major virulence factor /T. A. Russo, N. R. Luke, J. M. Beanan et al. //Infect. Immun. - 2010. - V. 78 (9). - P. 3993-4000.

63. The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-beta-1 -6-N-acetylglucosamine, which is critical for biofilm formation /A. H. Choi, L. Slamti, F. Y. Avci et al. //J. Bacteriol. - 2009. - V. 191. - P. 59535963.

64. Touchon M. The genomic diversification of the whole Acinetobacter genus: origins, mechanisms, and consequences //Genome Biol. Evol. - 2014. - V. 6. - P. 2866-2882.

65. Villegas M. V. Acinetobacter outbreaks, 1977-2000 /M. V. Villegas, A. I. Hartstein //Infect. Control Hosp. Epidemiol. - 2003. - V.24. - P. 284-295.

66. Weber B. S Genomic and functional analysis of the type VI secretion system in Acinetobacter //PLoS ONE. - 2013. - V. 8. -e55142.

67. Weiner L. M. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011-2014 // Infect. Control Hosp. Epidemiol. - 2016. - V. 37. - P. 1288-1301.


Рецензия

Для цитирования:


Лавриненко А.В. ВИРУЛЕНТНЫЙ ACINETOBACTER BAUMANNII. Медицина и экология. 2019;(3):24-29.

For citation:


Lavrinenko A.V. VIRULENT ACINETOBACTER BAUMANNII. Medicine and ecology. 2019;(3):24-29. (In Russ.)

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